prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.

The

solicitation number is NIH-NIDA-CSS-18-4915444

and the solicitation is issued as a request for quotation (RFQ).

This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Simplified Procedures for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold.

The associated NAICS code is 334516,

"Analytical Laboratory Instrument Manufacturing" and the small business size standard is 1,000 or fewer employees.

This acquisition is unrestricted, with no small business restrictions. Both large and small business offers shall be considered for award.

Statement of Need and Purpose:

The Dendrite Morphology and Plasticity Unit (DMPU) of the National Institute on Neurological Diseases and Stoke (NINDS), National Institutes of Health (NIH), will be culturing Drosophila S2 insect cells and dissociated neurons for the purposes of testing new genetic constructs and verifying the results of in vivo screens. A microscope is needed for easy imaging of these cultures. This will enable the DMPU to be more efficient in its research by removing the risk of introducing ineffective transgenes into its animal model. The expression of these constructs in S2 cells is often sub-optimal, and so DMPU needs an imaging system with the highest possible sensitivity.

Background Information and Objective:

The DMPU, NINDS uses various fluorescent markers to investigate the mechanisms of dendrite plasticity in its Drosophila model. These are genetically encoded or stained using antibodies. The process of developing these tools is very time-consuming and costly. The DMPU's goal is to rapidly test these tools in the early stages of development so that time is spent as efficiently as possible. This microscope will be used for the verification of these tools.

The DMPU requires the most advanced camera for confirmation of fluorophore expression in insect cells. The accompanying software must include extended depth-of-focus, which makes it possible to take more informative pictures of larger structures (such as whole fly brains).

Generic Name of Product

: (1) Inverted Light Microscope with imaging platform, (2) Digital Camera (attached to microscope and connected to a computer), (3) Associated image manipulation software.

Salient characteristics:

1. Microscope: The DMPU requires a size-appropriate for its purposes. The DMPU has space for a benchtop machine, within 50 cm x 80 cm x 80 cm, at or below 20 kg, with connected computer and monitor. Microscope and components must be easy to operate with the ability to be readily upgraded as DMPU's research needs may advance in the future. The microscope's working distance must be greater than 5 cm. The imaging platform must be adaptable to accommodate glass or plastic slides, well-plates, or culture flasks. The condenser turret must allow for Phase contrast, Epi-fluorescence, and DIC in 4X, 10X, 20X, or 40X magnification. The epi-fluorescent mechanism must enable separation of fluorescent channels, which is essential for the purposes of use of the requested equipment.

2. Camera: The camera shall have 16 megapixel resolution or better with good noise reduction, a high framerate (at least 35 fps at full field), and a large censor CMOS. This makes it possible to detect very faint fluorescent signals (<100 fluorescent molecules over a 25 cm2 area). This quality is the primary factor of the DMPU's decision to choose a model.

3. Software: The solftware must be easy-to-use system with a lot of customizability. Multi-channel images, including those with DIC, are easily merged, manipulated, and stored. The exported images shall be easily transferred to the DMPU's preferred image analysis software, Imaris. The Extended Depth of Focus module enhances the DMPU's ability to image in the Z-axis by combining a "stack" of images into one focused projection. This is necessary for imaging full brains and may prove insightful for imaging cultured cells.

Installation and Training Requirements:

All equipment and software should be installed by a certified technician.

At least two onsite training sessions are also required.

Quantity

: One microscope, one accompanying camera, and at least one software license. Contractor shall also complete Installation and conduct at least two on-site training sessions within 2 weeks of installation.

Delivery Schedule

: 30 days following receipt of order. At least two on-site training sessions to be conducted within 2 weeks of delivery and installation.

Warranty

: Industry standard for mechanics, optics and light source.

One year warranty on electronic components.

Purchase order will include four successive 12-month Term Options for extended warranty coverage on electronic components.

Contract Type

: A firm fixed price purchase order is anticipated for this acquisition. Additionally, four successive 12-month term options for extended warranty coverage of electronic components may be made part of the anticipated Purchase Order.

The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition.

The provision at FAR clause 52.212-2, Evaluation - Commercial Items, applies to this acquisition.

(a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to this solicitation will be most advantageous to the Government on the basis of lowest price, technically acceptable. The following factors shall be used to evaluate offers: In addition to price, the Government will award a contract on the basis of technical acceptability in accordance with the Salient Characteristics section of the Purchase Description, the vendor's ability to meet the required delivery schedule contained in the Delivery Date section, and the required warranty as indicated in the Warranty section of the Purchase Description contained in this combined synopsis/solicitation. Past performance shall also be considered.

(b) A written notice of award or acceptance of an offer, mailed or otherwise furnished to the successful offeror within the time for acceptance specified in the offer, shall result in a binding contract without further action by either party. Before the offer's specified expiration time, the Government may accept an offer (or part of an offer), whether or not there are negotiations after its receipt, unless a written notice of withdrawal is received before award.

The Offerors to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications-Commercial Items, with its offer.

The FAR clause at 52.212-4, Contract Terms and Conditions - Commercial Items, applies to this acquisition.

FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition. See attached document, "FAR 52.212-5 Applicable Clauses", for clauses applicable to this acquisition.

The following additional contract requirement(s) or terms and conditions as determined by the contracting officer are necessary for this acquisition and consistent with customary commercial practices:

[Applicable to the four successive one-year Term Options for extended warranty coverage]:

FAR 52.217-9 OPTION TO EXTEND THE TERM OF THE CONTRACT (March 2000).

a) The Government may unilaterally exercise any of the Term Options provided that the Government gives the Contractor a preliminary written notice of its intent to exercise said option at least 30 days prior to contract expiration. (Should it be the Government's intent to NOT exercise the next subsequent Term Option, the Government will notify the contractor 60 days prior to contract expiration in order to allow for the preparation of any final contract deliverables). The preliminary notice does not commit the Government to exercise the referenced Option.

b) If the Government exercises any of the Term Options, the extended contract shall be considered to include this option clause.

c) The total duration of the ordering period of the contract, including the exercise of any Term Options, under this clause, shall not exceed five years.

The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement.

Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.

In addition, the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov."

All responses must be received by 5 PM EST June 22, 2018 and reference number NIH-NIDA-CSS-18-4915444. Responses shall be submitted electronically to Jason Williams, Contracting Officer at willjas@nida.nih.gov

Fax responses will not be accepted.

For any questions or further information regarding this solicitation, please contact Jason Willliams, Contracting Officer, NINDS Contracts Management Branch, NIDA, NIH at PH: 301-496-5985; E-mail: willjas@nida.nih.gov

Attachments

Dates

Deadline: Friday, June 22, 2018

Date Published: Thursday, June 14, 2018

Date Updated: Thursday, June 14, 2018

Contact

Jason Williams

Jason.Williams1@nih.hhs.gov

6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland 20892-9559

(301) 496-5985

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